Natural Hosts of Siv: Implication in AIDS

Dr. Aftab A. Ansari, Professor, Department of Pathology and Laboratory Medicine, Room 2309 WMB, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA

Ph.D., University of Arizona, Tucson, Arizona, 1970

M.S., University of California, Los Angeles, CA, 1967

M.S., University of Karachi, Karachi, Pakistan, 1963

B.S., University of Karachi, Karachi, Pakistan, 1961

1981-present Senior Consultant, Naval Medical Research and Development Command, Bethesda, Maryland

1985-Present Professor, Department of Pathology and Laboratory Medicine, Emory University

1999-present Scientific Advisor, U.S. Naval Medical Research Unit #2, Jakarta, Indonesia.

2002-present Scientific Advisory Board, One World Health, San Francisco, CA.

2001-2008 Scientific Advisory Board, Lipid Sciences, Inc. Pleasanton, CA.

2005-present Scientific External Advisory Board member, CAHDR, Meharry Medical College,

Nashville, TN

2008-present Scientific Advisory Board, SMART Technologies, Inc., Rehovot, Israel

2007-present Member, FDA Expert Panel, FDA Center for Devices and Radiological Health

(CDRH), SGE, Deptt. Of Health & Human Services, Immunology Devices Panel

Chief, Division of Microbiology and Immunology, Yerkes National Primate Research Center

Georgia Research Alliance Eminent Scholar in Comparative Pathology, Emory University

Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant.

1. Overview Aftab Ansari and Guido Silvestri 2. Historical perspective Preston Marx 3. SIV infections in the wild Cristian Apetrei and Martine Peeters 4. Virology of SIVs Frank Kirchhoff 5. SIV infection of chimpanzees Jonathan Heeney, Edward James Donald Greenwood and Fabian Schmidt 6. Pathology of acute & chronic infection Francois Villinger and Sanjeev Gumber 7. Mucosal immunity Jason Brenchley 8. Innate immunity Steven E. Bosinger and R. Keith Reeves 9. Humoral immune responses Cynthia Ann Derdeyn and Reinhard Kurth 10. Cellular immune responses Amitinder Kaur 11. Chronic immune activation Donald Sodora 12. Pattern of infected cells Mirko Paiardini and Thomas Howerton Vanderford V 13. Viral transmission Ivona Pandrea and Ann Chahroudi 14. Genetics of the host Lutz Walter 15. The different modes of HIV/SIV control in monkeys and humans Lisa Chakrabarti 16. Humans resembling natural hosts Amalio Telenti and Paul McLaren Epilogue: Implications for HIV infection Aftab Ansari and Guido Silvestri