Advances in Immunology. Vol.111

Alt, Frederick W.Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

• Contributions from leading authorities and industry experts
• Informs and updates on all the latest developments in the field

1. Modeling a Complex Disease: Multiple Sclerosis

Florian C. Kurschus, Simone Wörtge and Ari Waisman

2. The IgH Locus 3' Regulatory Region: Pulling the Strings from Behind

Eric Pinaud, Marie Marquet, Rémi Fiancette, Sophie Péron, Christelle Vincent-Fabert, Yves Denizot and Michel Cogné

3. Transcriptional and Epigenetic Regulation of CD4/CD8 Lineage Choice

Ichiro Taniuchi and Wilfried Ellmeier

4. Autoinflammation by Endogenous DNA

Shigekazu Nagata and Kohki Kawane

5. AID targeting in Antibody Diversity

Rushad Pavri and Michel C. Nussenzweig