Cardiovascular Pharmacology: Endothelial Control

Cardiovascular Pharmacology: Endothelial Control
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Volume 60
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Artikel-Nr:
9780123850614
Veröffentl:
2010
Erscheinungsdatum:
07.12.2010
Seiten:
336
Gewicht:
586 g
Format:
237x159x19 mm
Sprache:
Englisch
Beschreibung:

Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. Presented in this volume of Advances in Pharmacology are some of the most promising possibilities for treating large numbers of individuals afflicted with these conditions.

Cardiovascular disease remains a major cause of death and disability in developed countries and, increasingly so, in the developing world. This is driven in part by demographics and the increase in longevity, and the obesity-metabolic syndrome-diabetes-atherosclerosis continuum that is reaching pandemic proportions. Accordingly, the discovery of novel targets involved in cardiovascular disease, and the design of small molecules or biologics that interact with these sites, still holds the greatest promise for treating large numbers of individuals afflicted with these conditions. Presented in this volume of Advances in Pharmacology are some of the most promising possibilities in that regard.
1. The Cardiovascular Physiology and Pharmacology of Endothelin-1 2. Vascular Pharmacology of Epoxyeicosarienoic Acids 3. Prostaglandins in Action: Indispensable Roles of Cyclooxygenase-1 and 2 in Endothelium-dependent Contractions 4. TP Receptors and Oxidative Stress: Hand in Hand from Endothelial Dysfunction to Atherosclerosis 5. Regulation of Endothelial Cell Tetrahydrobiopterin: Pathophysiological and Therapeutic Implications 6. Polyphenol-Induced Endothelium-Dependent Relaxations: Role of NO and EDHF 7. Organic Nitrates and Nitrate Tolerance - State of the Art and Future Developments 8. Vascular Actions of Adipokines: Molecular Mechanism and Therapeutic Intervention 9. Cardiovascular Effects of Erythropoietin: An Update

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