HDL Handbook

The HDL Handbook: Biological Functions to Clinical Implications brings laboratory research in HDL from bench to bedside in this needed resource for researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. In addition, researchers and clinicians working with an aging population, corporate researchers, post-doctorates; medical students and graduate students will find this publication useful because the scope of coverage includes basic science, genetics, epidemiology, and treatment of HDL cholesterol as well as potential targets to modify HDL cholesterol. Comprehensive coverage of basic science, genetics, epidemiology and treatment Reputable content on latest advances in HDL cholesterol research Inclusive, worldwide content with country specific information In depth discussion of potential targets to modify HDL

The HDL Handbook: Biological Functions to Clinical Implications brings laboratory research in HDL from bench to bedside in this needed resource for researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. In addition, researchers and clinicians working with an aging population, corporate researchers, post-doctorates; medical students and graduate students will find this publication useful because the scope of coverage includes basic science, genetics, epidemiology, and treatment of HDL cholesterol as well as potential targets to modify HDL cholesterol. Comprehensive coverage of basic science, genetics, epidemiology and treatment Reputable content on latest advances in HDL cholesterol research Inclusive, worldwide content with country specific information In depth discussion of potential targets to modify HDL

1;Front Cover;12;The HDL Handbook;43;Copyright;54;Contents;65;Preface;86;Contributors;107;Chapter 1Role of Phospholipid Transfer Protein in HDL Remodeling and Atherosclerosis;147.1;Introduction;147.2;Molecular biology and structure of phospholipid transfer protein;157.3;PLTP-mediated lipid transfer;177.4;PLTP-mediated HDL remodeling;177.5;Genetically modified animals;187.6;PLTP and atherosclerosis in humans;227.7;Conclusion;237.8;References;238;Chapter 2The Role of Cholesteryl Ester Transfer Protein (CETP) in HDL Metabolism;308.1;Introduction;308.2;Molecular biology;318.3;Effect of CETP action on HDL structure;338.4;Effect of CETP activity on plasma HDL levels and atherosclerotic disease;338.5;Effect of CETP activity on HDL function and consequences for atherosclerotic disease;358.6;Polymorphisms of the CETP gene and interactions between environmental influences and HDL;398.7;Inhibitors of CETP activity as therapy;408.8;Conclusion;418.9;References;419;Chapter 3Plasma Cholesteryl Ester Transfer Protein (CETP) in Relation to Human Pathophysiology;489.1;Introduction;489.2;Structure of CETP;509.3;Regulation of CETP expression;509.4;Function of CETP;519.5;Role of CETP in apoE-rich HDL formation;549.6;Molecular genetics and the ethnic difference in the frequency of human CETP deficiency;559.7;Clinical chemistry of LDL-cholesterol and HDL-cholesterol in CETP deficiency;569.8;Epidemiology of increased HDL cholesterol levels and CETP deficiency;579.9;Development of a CETP inhibitor;599.10;Role of CETP in aging and longevity;619.11;Role of CETP in dyslipidemia associated with diabetes and metabolic syndrome;639.12;Clinical Trials of CETP inhibitors;649.13;Low CETP status, genetic or environmental?;649.14;References;6410;Chapter 4HDL and Reverse Cholesterol Transport: Physiological Modulation;7410.1;Influence of aging on the reverse cholesterol transport pathway;7410.2;Influence of hormones on the reverse cholesterol transport pathway;7410.3;Influence of physical activity on the reverse cholesterol transport pathway;7810.4;Influence of diet on the reverse cholesterol transport pathway;7910.5;Influence of alcohol consumption on the reverse cholesterol transport pathway;8010.6;Influence of smoking on the reverse cholesterol transport pathway;8110.7;Influence of postprandial state on the reverse cholesterol transport pathway;8210.8;Conclusion;8410.9;Acknowledgments;8410.10;References;8411;Chapter 5Serum Paraoxonase (PON1) and its Interactions with HDL: Relationship between PON1 and Oxidative Stress;9011.1;Introduction;9011.2;HDL - structure, heterogeneity and anti-atherogenic properties;9111.3;Paraoxonase-1 (PON1);9511.4;The association between PON1 and HDL;9611.5;Conclusion;10511.6;References;10512;Chapter 6Paraoxonase-1 and its Interactions with HDL: Molecular Structures ofnbspPON1nbspand HDL;11212.1;Introduction;11212.2;PON1 as a promiscuous human plasma enzyme;11512.3;HDL molecular environment of PON1;11912.4;Impediments for studying the passenger PON1 andnbspthe vehicle HDL;12112.5;PON1 activity in normal HDL conditions;12512.6;PON1 activity in altered HDL conditions;12812.7;PON1 activity in therapeutic HDL;13112.8;Conclusion;13412.9;References;13513;Chapter 7Apolipoprotein A-I Mutations;14613.1;Introduction;14613.2;GENOMIC AND PROTEIN STRUCTURE OF APOA-I;14713.3;PHYSIOLOGICAL FUNCTIONS OF APOA-I;14713.4;APOA-I DEFICIENCIES WITH LARGE DELETION, NONSENSE OR FRAMESHIFT MUTATIONS;14813.5;APOLIPOPROTEIN A-I VARIANTS;15213.6;REFERENCES;15714;Chapter 8The Scavenger Receptor Class B Type I: An HDL Receptor Involved in Lipid Transport and HDL Dependent Signaling;16614.1;Overview;16614.2;Role of SR-BI in HDL metabolism, atherosclerosis and coronary heart disease - studies from genetically altered mice;16614.3;SR-BI mediated HDL lipid uptake and efflux;16814.4;Cellular Biology of SR-BI: Localization;16914.5;SR-BI-mediated endocytosis of HDL;17214.6;Multime