Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors
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Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of its Inhibitors

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ISBN-13:
9780123813275
Einband:
EPUB
Seiten:
336
Autor:
Erkki Nissinen
Serie:
ISSN
eBook Typ:
Adobe Digital Editions
eBook Format:
EPUB
Kopierschutz:
Adobe DRM [Hard-DRM]
Sprache:
Englisch
Beschreibung:

Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson's disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitorsPreclinical models in COMT inhibitor devlopmentTransgenic COMT mice - latest information summarizedChemistry of COMT inhibitors and their design with molecular modellingCOMT gene and its regulation and relation to dopamine related diseasesRole of cofactor SAM regulation in relation to homocysteineNonclinical and clinical safety of COMT inhibitors summarizedFuture prospects of COMT inhibitors in Parkinson's disease
Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson's disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitorsPreclinical models in COMT inhibitor devlopmentTransgenic COMT mice - latest information summarizedChemistry of COMT inhibitors and their design with molecular modellingCOMT gene and its regulation and relation to dopamine related diseasesRole of cofactor SAM regulation in relation to homocysteineNonclinical and clinical safety of COMT inhibitors summarizedFuture prospects of COMT inhibitors in Parkinson's disease