Glycosaminoglycans in Development, Health and Disease

Lijuan Zhang is a Professor of Translational Medicine at Ocean University of China. She completed her doctorates of biochemistry and molecular genetics at University of Alabama at Birmingham in 1995. Before then, she was a Fogarty International Fellow at NIH for three years studying glycan-based cancer biomarkers. She worked as post-doctorate fellow and research associate at both MIT and Harvard Medical School from 1995-2002. She joined the faculty of the Department of Pathology & Immunology at Washington University in St. Louis in 2002 as a tenure-tracked Assistant Professor. Her research had been focused on the biosynthesis, structures, and biological functions of glycans since 1985. Now her work is on translational aspects of glycans as biomarkers and therapeutics. She has over 60 peer reviewed publications. She edited and published a book entitled "Glycosaminoglycans in Development, Health, and Diseases” with the contributions of top scientists worldwide in 2010 by Elsevier.

Glycosaminoglycans (GAGs) are a family of linear polysaccharides that are found in all animal tissues. Several are used as biomaterials, including heparin, heparin sulfate, keratan sulfate, dermatan sulfate, and chondroitin sulfate.

This volume discusses the role of GAGs in development, health and disease.

1. Mice deficient in heparan sulfate N-sulphotransferase-1

Lena Kjellén and Maria Ringvall

2. Mice deficient in heparan sulfate epimerase

Jin ping Li

3. Mice deficient in heparan sulfate 3-O-sulfotransferase-1 Nicholas W. Shworak
4. Mice deficient in heparan sulfate 6-O-sulfotransferase-1

Koji Kimata and Hiroko Habuchi

5. Mice deficient in dermatan sulfate Epimerase

Marco Maccarana and Anders Malmström

6. The roles of chondroitin-4-sulfotransferase-1 in development and disease

Michael Klüppel

7. Conditionally disrupted EXT1 in the embryonic mouse brain.

Yu Yamaguchi

8. Endothelial heparan sulfate in inflammation

Jeffrey D. Esko and Ding Xu

9. Endothelial heparan sulfate in angiogenesis

Jeffrey D. Esko, Mark M. Fuster and Lianchun Wang

10. Hepatocyte heparan sulfate and lipoprotein metabolism

Jeffrey D. Esko and Erin Foley

11. Serglycin proteoglycan deletion in mouse platelet

Barbara P. Schick

12. GAGs in Amyloidosis

Jin ping Li and Xiao Zhang

13. Selectins, Heparins and Tumor Metastasis

Lubor Borsig

14. Chondroitin sulfate and Rheumatoid arthritis

Lijuan Zhang

15. Adducted thumb-clubfoot syndrome (ACTS) and Loss of dermatan-4-sulfotransferase 1 function

Jacques U Baenziger,Thomas Müller, Andreas Janecke and Lijuan Zhang

16. Vascular dermatan sulfate and heparin cofactor II

Douglas M. Tollefsen

17. Diverse Functions of Glycosaminoglycans in Infectious Diseases

Pyong Woo Park, Rafael Aquino, and Eui Seung Lee

18. Lessons learned from contaminated heparin. 1: Molecular mechanism underlines heparin induced thrombocytopenia and thrombosis.

Lijuan Zhang

19. Lessons learne from contaminated heparin. 2: Contact System Activation-induced Thrombin in Unrelated Human Thromboembolic Diseases

Lijuan Zhang, Peter Weiser, Yi Qian and Jing Pan