Glycosaminoglycans in Development, Health and Disease

Glycosaminoglycans in Development, Health and Disease
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Volume 93
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Artikel-Nr:
9780123812827
Veröffentl:
2010
Erscheinungsdatum:
15.09.2010
Seiten:
408
Gewicht:
874 g
Format:
234x160x35 mm
Sprache:
Englisch
Beschreibung:

Lijuan Zhang is a Professor of Translational Medicine at Ocean University of China. She completed her doctorates of biochemistry and molecular genetics at University of Alabama at Birmingham in 1995. Before then, she was a Fogarty International Fellow at NIH for three years studying glycan-based cancer biomarkers. She worked as post-doctorate fellow and research associate at both MIT and Harvard Medical School from 1995-2002. She joined the faculty of the Department of Pathology & Immunology at Washington University in St. Louis in 2002 as a tenure-tracked Assistant Professor. Her research had been focused on the biosynthesis, structures, and biological functions of glycans since 1985. Now her work is on translational aspects of glycans as biomarkers and therapeutics. She has over 60 peer reviewed publications. She edited and published a book entitled "Glycosaminoglycans in Development, Health, and Diseases” with the contributions of top scientists worldwide in 2010 by Elsevier.

Glycosaminoglycans (GAGs) are a family of linear polysaccharides that are found in all animal tissues. Several are used as biomaterials, including heparin, heparin sulfate, keratan sulfate, dermatan sulfate, and chondroitin sulfate.

This volume discusses the role of GAGs in development, health and disease.

  1. Mice deficient in heparan sulfate N-sulphotransferase-1
  2. Lena Kjellén and Maria Ringvall

  3. Mice deficient in heparan sulfate epimerase
  4. Jin ping Li

  5. Mice deficient in heparan sulfate 3-O-sulfotransferase-1 Nicholas W. Shworak
  6. Mice deficient in heparan sulfate 6-O-sulfotransferase-1
  7. Koji Kimata and Hiroko Habuchi

  8. Mice deficient in dermatan sulfate Epimerase
  9. Marco Maccarana and Anders Malmström

  10. The roles of chondroitin-4-sulfotransferase-1 in development and disease
  11. Michael Klüppel

  12. Conditionally disrupted EXT1 in the embryonic mouse brain.
  13. Yu Yamaguchi

  14. Endothelial heparan sulfate in inflammation
  15. Jeffrey D. Esko and Ding Xu

  16. Endothelial heparan sulfate in angiogenesis
  17. Jeffrey D. Esko, Mark M. Fuster and Lianchun Wang

  18. Hepatocyte heparan sulfate and lipoprotein metabolism
  19. Jeffrey D. Esko and Erin Foley

  20. Serglycin proteoglycan deletion in mouse platelet
  21. Barbara P. Schick

  22. GAGs in Amyloidosis
  23. Jin ping Li and Xiao Zhang

  24. Selectins, Heparins and Tumor Metastasis
  25. Lubor Borsig

  26. Chondroitin sulfate and Rheumatoid arthritis
  27. Lijuan Zhang

  28. Adducted thumb-clubfoot syndrome (ACTS) and Loss of dermatan-4-sulfotransferase 1 function
  29. Jacques U Baenziger,Thomas Müller, Andreas Janecke and Lijuan Zhang

  30. Vascular dermatan sulfate and heparin cofactor II
  31. Douglas M. Tollefsen

  32. Diverse Functions of Glycosaminoglycans in Infectious Diseases
  33. Pyong Woo Park, Rafael Aquino, and Eui Seung Lee

  34. Lessons learned from contaminated heparin. 1: Molecular mechanism underlines heparin induced thrombocytopenia and thrombosis.
  35. Lijuan Zhang

  36. Lessons learne from contaminated heparin. 2: Contact System Activation-induced Thrombin in Unrelated Human Thromboembolic Diseases

Lijuan Zhang, Peter Weiser, Yi Qian and Jing Pan

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