Handbook of Toxicology of Chemical Warfare Agents

This groundbreaking book covers every aspect of deadly toxic chemicals used as weapons of mass destruction and employed in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this one-of-a-kind handbook is prepared in a very user- friendly format that can easily be followed by students, teachers and researchers, as well as lay people. Stand-alone chapters on individual chemicals and major topics allow the reader to easily access required information without searching through the entire book.This is the first book that offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors, biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, prophylactic, therapeutic and countermeasures, and the role of homeland security. Presents a comprehensive look at all aspects of chemical warfare toxicology in one reference work. This saves researchers time in quickly accessing the very latest definitive details on toxicity of specific agents used in chemical warfare as opposed to searching through thousands of journal articles. Will include the most agent-specific information on the market Includes detailed coverage of the most exhaustive list of agents possibly used as chemical warfare agents in one source. Section 4: Agents That Can Be Used as Weapons of Mass Destruction ? 25 chapters long. Other books on the market only include a sample selection of specific agents. Offering all possible agents detailed under one cover makes this appealing to a wider audience and saves researchers time The Forward will be written by Dr. Tetsuo Satoh, Chiba University, Japan. He is one of the most respected, recognizable authorities on chemical warfare agents which will set the authoritative tone for the book Covers risk to humans, animals and the environment equally. Researchers involved in assessing the risks involved with a possible chemical warfare attack and those who are developing response plans to such attacks must look at not only the risks to human health but to our wildlife and environment as well. The holistic approach taken in this book ensures that the researchers have ready access to the details no matter which aspect of the effects of CWA's they might be concerned with

This groundbreaking book covers every aspect of deadly toxic chemicals used as weapons of mass destruction and employed in conflicts, warfare and terrorism. Including findings from experimental as well as clinical studies, this one-of-a-kind handbook is prepared in a very user- friendly format that can easily be followed by students, teachers and researchers, as well as lay people. Stand-alone chapters on individual chemicals and major topics allow the reader to easily access required information without searching through the entire book.This is the first book that offers in-depth coverage of individual toxicants, target organ toxicity, major incidents, toxic effects in humans, animals and wildlife, biosensors, biomarkers, on-site and laboratory analytical methods, decontamination and detoxification procedures, prophylactic, therapeutic and countermeasures, and the role of homeland security. Presents a comprehensive look at all aspects of chemical warfare toxicology in one reference work. This saves researchers time in quickly accessing the very latest definitive details on toxicity of specific agents used in chemical warfare as opposed to searching through thousands of journal articles. Will include the most agent-specific information on the market Includes detailed coverage of the most exhaustive list of agents possibly used as chemical warfare agents in one source. Section 4: Agents That Can Be Used as Weapons of Mass Destruction ? 25 chapters long. Other books on the market only include a sample selection of specific agents. Offering all possible agents detailed under one cover makes this appealing to a wider audience and saves researchers time The Forward will be written by Dr. Tetsuo Satoh, Chiba University, Japan. He is one of the most respected, recognizable authorities on chemical warfare agents which will set the authoritative tone for the book Covers risk to humans, animals and the environment equally. Researchers involved in assessing the risks involved with a possible chemical warfare attack and those who are developing response plans to such attacks must look at not only the risks to human health but to our wildlife and environment as well. The holistic approach taken in this book ensures that the researchers have ready access to the details no matter which aspect of the effects of CWA's they might be concerned with

1;Front Cover;12;Handbook of Toxicology of Chemical warfare agents;43;Copyright Page;54;Dedication;65;Contents;86;List of Contributors;127;Foreword;188;SECTION I Introduction, Historical Perspective, and Epidemiology;208.1;CHAPTER 1 - Introduction;228.2;CHAPTER 2 - Historical Perspective of Chemical Warfare Agents;268.2.1;I. INTRODUCTION;268.2.2;II. THE FIRST SUSTAINED USE OFCHEMICALS AS AGENTS OF WARFARE;278.2.3;III. INITIAL COUNTERMEASURES;288.2.4;IV. EVENTS AFTER WORLD WAR I;298.2.5;V. WORLD WAR II;308.2.6;VI. POST-WORLD WAR II;318.2.7;VII. INCAPACITANTS AND TOXINS;328.2.8;VIII. RECENT EXPERIENCES;338.2.9;IX. TERRORIST USE;348.2.10;X. CONCLUDING REMARKSAND FUTURE DIRECTION;348.2.11;References;348.3;CHAPTER 3 - Global Impact of Chemical Warfare Agents Used Before and After 1945;368.3.1;I. INTRODUCTION;368.3.2;II. BACKGROUND;368.3.3;III. MILITARY USE OF CWs;378.3.4;IV. THE PERIOD BETWEEN WWIAND WWII;378.3.5;V. WWII;378.3.6;VI. THE PERIOD AFTER WWIIAND THE COLD WAR;398.3.7;VII. UNINTENTIONAL USE OF TOXICCHEMICALS;418.3.8;VIII. TERRORIST USE OF CW;418.3.9;IX. NEGOTIATIONS;418.3.10;X. CONCLUDING REMARKSAND FUTURE DIRECTION;428.3.11;References;428.4;CHAPTER 4 - The Tokyo Subway Sarin Attack: Toxicological Whole Truth;448.4.1;I. INTRODUCTION;448.4.2;II. SARIN TOXICITY AND MECHANISMOF ONSET;448.4.3;III. OVERVIEW OF THE TOKYO SUBWAYSARIN ATTACK;458.4.4;IV. EMERGENCY TREATMENTOF SARIN TOXICITY;468.4.5;V. ACUTE AND CHRONIC SYMPTOMSOF SARIN TOXICITY;488.4.6;VI. LABORATORY FINDINGS IN SARINTOXICITY;498.4.7;VII. CONCLUDING REMARKSAND FUTURE DIRECTION;498.4.8;Acknowledgments;508.4.9;References;508.5;CHAPTER 5 - Epidemiology of Chemical Warfare Agents;528.5.1;I. INTRODUCTION;528.5.2;II. PRE-WORLD WAR II;528.5.3;III. WORLD WAR II;528.5.4;IV. POST-WORLD WAR II;538.5.5;V. IRAN-IRAQ WAR;548.5.6;VI. GULF WAR 1991;548.5.7;VII. TERRORISM;568.5.8;VIII. CONCLUDING REMARKSAND FUTURE DIRECTION;578.5.9;References;579;SECTION II Agents that can be Used as Weapons of Mass Destruction;609.1;CHAPTER 6 Organophosphate Nerve Agents;629.1.1;I. INTRODUCTION;629.1.2;II. BACKGROUND;629.1.3;III. MECHANISM OF ACTION;639.1.4;IV. TOXICITY;669.1.5;V. RISK ASSESSMENT;749.1.6;VI. TREATMENT;769.1.7;VII. CONCLUDING REMARKS ANDFUTURE DIRECTION;789.1.8;Acknowledgments;799.1.9;References;799.2;CHAPTER 7 Russian VX ;889.2.1;I. INTRODUCTION;889.2.2;II. BACKGROUND;889.2.3;III. MECHANISMS OF ACTIONAND TOXICITY;959.2.4;IV. TOXICOMETRY AND HYGIENICREGULATIONS;1039.2.5;V. PRINCIPLES OF THERAPY;1039.2.6;VI. CONCLUDING REMARKSAND FUTURE DIRECTION;1049.2.7;References;1069.3;CHAPTER 8 Mustards and Vesicants;1129.3.1;I. INTRODUCTION;1129.3.2;II. HISTORY AND BACKGROUND;1159.3.3;III. TOXICOKINETICS;1169.3.4;IV. MECHANISM OF ACTION;1179.3.5;V. TOXICITY;1189.3.6;VI. RISK ASSESSMENT;1229.3.7;VII. TREATMENT;1239.3.8;VIII. CONCLUDING REMARKSAND FUTURE DIRECTION;1239.3.9;References;1239.4;CHAPTER 9 Arsenicals: Toxicity, their Use as Chemical Warfare Agents, and Possible Remedial Measures;1289.4.1;I. INTRODUCTION;1289.4.2;II. BACKGROUND;1289.4.3;III. ARSINE;1299.4.4;IV. ORGANIC ARSENICALS;1339.4.5;V. INORGANIC ARSENIC;1399.4.6;VI. TREATMENT;1429.4.7;VII. CONCLUDING REMARKSAND FUTURE DIRECTION;1459.4.8;References;1469.5;CHAPTER 10 Psychotomimetic Agent BZ (3-Quinuclidinyl Benzilate);1549.5.1;I. INTRODUCTION;1549.5.2;II. BACKGROUND;1549.5.3;III. TOXICOKINETICS AND MECHANISMOF ACTION;1549.5.4;IV. TOXICITY;1569.5.5;V. RISK ASSESSMENT;1579.5.6;VI. TREATMENT;1589.5.7;VII. ANALYTICAL METHODS;1599.5.8;VIII. CONCLUDING REMARKSAND FUTURE DIRECTION;1609.5.9;References;1609.6;CHAPTER 11 Onchidal and Fasciculins;1629.6.1;I. INTRODUCTION;1629.6.2;II. BACKGROUND;1629.6.3;III. MECHANISM OF ACTIONAND BIOLOGICAL EFFECTS;1659.6.4;IV. EXPERIMENTAL AND HUMANTOXICITY;1669.6.5;V. RISK ASSESSMENT;1679.6.6;VI. TREATMENT;1709.6.7;VII. CONCLUDING REMARKSAND FUTURE DIRECTION;1709.6.8;Acknowledgment;1709.6.9;