Studies in Natural Products Chemistry

Rapid advances in chromatographic procedures, spectroscopic techniques and pharmacological assay methods have resulted in the discovery of an increasing number of new and interesting natural products from terrestrial and marine sources. The present volume contains comprehensive reviews on some of the major advances in this field which have taken place in recent years. The reviews include those on: novel metabolites from marine gastropods; the chemistry of marine natural products of the Halenaquinol family; secondary metabolites from Echinoderms and Bryozoans; triterpenoids and aromatic compounds from medicinal plants; chemistry and activity of sesquiterpenes from the genus Lactarius; the chemistry of bile alcohols; antifungal sesquiterpene dialdehydes; annonaceous acetogenins; nargenicin macrolides; and lignans and diarylheptanoids. Tropane alkaloids and phenolides formed by root cultures are also reviewed. Articles on natural Diels-Alder type adducts, the use of computer aided overlay for modelling the substrate binding domain of HLADH, applications of 170 NMR spectroscopy to natural product chemistry and the role of biological raw materials in synthesis are included. Volume 17 provides material of interest to natural products chemists.

Rapid advances in chromatographic procedures, spectroscopic techniques and pharmacological assay methods have resulted in the discovery of an increasing number of new and interesting natural products from terrestrial and marine sources. The present volume contains comprehensive reviews on some of the major advances in this field which have taken place in recent years. The reviews include those on: novel metabolites from marine gastropods; the chemistry of marine natural products of the Halenaquinol family; secondary metabolites from Echinoderms and Bryozoans; triterpenoids and aromatic compounds from medicinal plants; chemistry and activity of sesquiterpenes from the genus Lactarius; the chemistry of bile alcohols; antifungal sesquiterpene dialdehydes; annonaceous acetogenins; nargenicin macrolides; and lignans and diarylheptanoids. Tropane alkaloids and phenolides formed by root cultures are also reviewed. Articles on natural Diels-Alder type adducts, the use of computer aided overlay for modelling the substrate binding domain of HLADH, applications of 170 NMR spectroscopy to natural product chemistry and the role of biological raw materials in synthesis are included. Volume 17 provides material of interest to natural products chemists.

1;Cover;12;Contents;103;Foreword;64;Preface;85;Contributors;126;Chapter 1. Novel secondary metabolites of marine gastropods;187;Chapter 2. Total synthesis and absolute stereochemistry of novel biologically active marine natural products of Halenaquinol family: Theoretical studies of CD spectra;488;Chapter 3. Bryozoan secondary metabolites and their chemical ecology;889;Chapter 4. Structure and biological activity of triteipenoids and aromatic compounds from medicinal plants;12810;Chapter 5. Sesquiteipenes and other secondary metabolites of genus Lactarius (Basidiomycetes): Chemistry and biological activity;16811;Chapter 6. Structure and biosynthesis of bile alcohols: Disorders of choylesterol side-chain oxidation in cerebrotendinous xanthomatosis;22212;Chapter 7. Antifungal sesquiteipene dialdehydes from the Warburgia plants and their synergists;24813;Chapter 8. Determination of relative and absolute configuration in the Annonaceous acetogenins;26614;Chapter 9. The chemistry of the nargenicin macrolides;29815;Chapter 10. Some aspects of the chemistry of lignans;32616;Chapter 11. The chemistiy of natural diarylheptanoids;37217;Chapter 12. Tropane alkaloids in root cultures of Solanaccous plants;41018;Chapter 13. Phenolics in root cultures of medicinal plants;43619;Chapter 14. Chemistry and biosynthesis of natural Diels-Alder type adducts from Moraceous plants;46620;Chapter 15. Modelling the substrate binding domain of horse liver alcohol dehydrogenase, HLADH, by computer aided substrate overlay;49421;Chapter 16. Applications of 17O NMR spectroscopy to natural products chemistry;56422;Chapter 17. The role of biological raw materials in synthesis;61623;Subject Index;670