Novel Insights in the Neurochemistry and Function of Pulmonary Sensory Receptors

With the advances of immunohistochemistry in combination with confocal microscopy, airway sensory receptor end-organs can now be examined and evaluated objectively. Based on their ‘neurochemical coding’, morphology, location and origin, three sensory receptor end organs are currently morphologically well-characterised: smooth muscle-associated airway  receptors (SMARs), neuroepithelial bodies (NEBs) and visceral pleura receptors (VPRs). The present information on the functional morphological and neurochemical characteristics of these sensory receptors, leads to important conclusions about their (possible) function.

Sensory nerve terminals in intrapulmonary airways and lungs.- Electrophysiologicalls identified airway receptors: main characteristics.- Morphology and location of electrophysiologically identified sensory airway receptors.- The neurochemical coding of airway afferents.- Morphologically identified sensory receptor end-organs in the airways, lungs and visceral pleura.- In situ functional imaging of sensory receptors in lung models.- Concluding remarks and future prospects.- Subject index