Computational Systems-Biology and Bioinformatics

This CCIS volume constitutes the proceedings of the First International Conference on Computational Systems Biology and Bioinformatics (CSBio 2010), held in Bangkok, Thailand, November 3 5, 2010. CSBio 2010 was a follow up to the successful Special th Session on Computational Advances in Bioinformatics (CAB 2009) in the 16 International Conference on Neural Information Processing (ICONIP 2009). CSBio will provide an annual forum for international researchers to exchange the latest ideas on advances in the interdisciplinary fields of computational systems biology and bioinformatics. CSBio is proposed to be hosted alternately by King Mongkut s University of Technology Thonburi (KMUTT), Thailand, and Nanyang Technological University (NTU), Singapore. The School of Information Technology (SIT) at KMUTT was the proud host of CSBio 2010. This inaugural conference was launched th th to coincide with the 15 anniversary of SIT and the 50 anniversary of KMUTT. CSBio 2010 accepted 19 regular session papers from a total of 48 submissions received on the EasyChair conference system. The authors of the submitted papers covered 16 countries worldwide and there were over 60 authors in the conference proceedings. The technical sessions were divided into five topical categories. Technical highlights included a keynote speech by Michael Brudno (Canada Research Chair in Computational Biology) and plenary talks by Nikhil R. Pal, Sung-Bae Cho, Yaochu Jin, and David W. Ussery. In addition, three tutorials by Kwoh Chee Keong, Stijn Meganck and Philip Shaw were included with CSBio 2010 registration.

Session 1. Modeling and Simulation of Biological Processes.- A Formal Model for Gene Regulatory Networks with Time Delays.- Modelling fim Expression in Escherichia Coli K12.- Study of the Structural Pathology Caused by CYP2C9 Polymorphisms towards Flurbiprofen Metabolism Using Molecular Dynamics Simulation.- 3D Structure Modeling of a Transmembrane Protein, Fatty Acid Elongase.- Session 2. Gene Expression Analysis.- Sequential Application of Feature Selection and Extraction for Predicting Breast Cancer Aggressiveness.- On Assigning Individuals from Cryptic Population Structures to Optimal Predicted Subpopulations: An Empirical Evaluation of Non-parametric Population Structure Analysis Techniques.- Extended Constraint-Based Boolean Analysis: A Computational Method in Genetic Network Inference.- Mining LINE-1 Characteristics That Mediate Gene Expression.- Session 3. Biological Sequence Analysis and Network Reconstruction.- Mining Regulatory Elements in Non-coding Regions of Arabidopsis thaliana.- Prediction of Non-coding RNA and Their Targets in Spirulina platensis Genome.- Reconstruction of Starch Biosynthesis Pathway in Cassava Using Comparative Genomic Approach.- Session 4. Bio-data Visualization and Biological Databases.- Catalog of Genetic Variations (SNPs and CNVs) and Analysis Tools for Thai Genetic Studies.- The Genome Atlas Resource.- INVERTER: INtegrated Variable numbER Tandem rEpeat findeR.- Design of an Enterobacteriaceae Pan-Genome Microarray Chip.- Session 5. Medical and Biomedical Informatics.- Multi-objective Particle Swarm Optimisation for Phase Specific Cancer Drug Scheduling.- A Vaccine Strategy for Plant Allergy by RNA Interference - An in Silico Approach.- Unsupervised Algorithms for Population Classification and Ancestry Informative MarkerSelection.- Genome-Based Screening for Drug Targets Identification: Application to Typhoid Fever.