Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer

Lisa A. Newman, MD, MPH, FACS
Professor of Surgery, Director, Breast Care Center, University of Michigan Health System, Comprehensive Cancer Center, Ann Arbor, MI, USA

Jessica M. Bensenhaver, MD
Assistant Professor of Surgery, University of Michigan Health System, Comprehensive Cancer Center, Ann Arbor, MI, USA

This volume reviews the evolution of information regarding the epidemiology of DCIS and its modes of detection, as well as treatment options as a function of both clinical trial data and ongoing investigational therapeutic prospects. Several of the challenging and clinically-relevant scenarios of DCIS that appear in daily practice is discussed, including the difficulties of distinguishing "true" DCIS from borderline patterns of other breast diseases and the therapeutic implications of differentiating these various diagnoses. Particular attention is paid to pathologic evaluation of DCIS, including histologic patterns and the importance of margin evaluation/margin control. The text also explores the data regarding DCIS in medical research in hereditary susceptibility for breast cancer and race/ethnicity-associated disparities in breast cancer.

Written by experts in the field, Ductal Carcinoma In Situ and Microinvasive/Borderline Breast Cancer is a comprehensive, state-of-the art review of the field, and serves as a valuable resource for clinicians, surgeons and researchers with an interest in breast cancer.

Provides challenging and clinically-relevant scenarios

1. Epidemiology of Ductal Carcinoma In Situ
Prathima Kanumuri and Anees Chagpar

2. Role of Screening Mammography in Early Detection/Outcome from Breast Cancer
Renee W. Pinsky and Mark A. Helvie

3. Imaging DCIS: Digital/Film Screening Mammography, Tomosynthesis, MRI, Ultrasonography
Annette Ingram Joe and Stephanie K. Patterson

4. Pathology of Ductal Carcinoma In Situ: Features and Diagnostic Challenges
Julie M. Jorns and Celina G. Kleer

5. Molecular Markers in DCIS
Chelsea Horwood and Theresa L. Schwartz

6. History of Ductal Carcinoma In Situ Management Based Upon Data from Prospective, Randomized Clinical Trials
Lisa A. Newman and Jessica M. Bensenhaver

7. Extent and Role of Margin Control for DCIS Managed by Breast-Conserving Surgery
Melissa Pilewskie and Monica Morrow

8. Ductal Carcinoma In Situ Treated With Breast Conserving Surgery Alone
Jessica M. Bensenhaver

9. DCIS Managed with BCS: Whole-Breast XRT vs. Partial Breast XRT
Chirag Shah and Frank A. Vicini

10. Anti-HER2/neu Therapy in DCIS
Amelia Tower, Ruta D. Rao, Kalliopi P. Siziopikou, Melody A. Cobleigh and Thomas B. Julian

11. Role of Genetic Profiling and Recurrence Scores in Treatment Planning for DCIS
Julie A. Margenthaler and Amy E. Cyr

12. DCIS and Sentinel Lymph Node Biopsy
Alfred J. Colfry, 3rd, Alastair M. Thompson and Henry Mark Kuerer

13. Role of Postmastectomy Radiation for DCIS
Corey W. Speers and Reshma Jagsi

14. Monitoring and Surveillance Following DCIS Treatment
Jennifer Zakhireh and E. Shelley Hwang

15. DCIS and Hereditary Susceptibility for Breast Cancer
Patrick Pilie, Kara Milliron and Sofia D. Merajver

16. Introduction, Evolution and Application of the Van Nuys Prognostic Index in DCIS
Aeisha K. S. Rivers

17. Disparities in DCIS Detection and Outcomes Related to Race/Ethnicity
Erin A. Strong, Azadeh Stark and Lisa A. Newman