High Density Lipoproteins, Dyslipidemia, and Coronary Heart Disease

This innovative book focuses on HDL and its relationships to triglyceride-rich particles. As new therapies for HDL raising become available, a comprehensive understanding the role of HDL in Coronary Heart Disease is of great importance. This book is an excellent resource for educating physicians and scientists about dyslipidemia and HDL metabolism, including many exogenous substances which interact with and influence HDL. Readers will benefit from the unique visual exposition and the insights of international experts.

Presents visual exposition of cutting-edge principles in cholesterol metabolism

Introduction: HDL, Dyslipidemia, and Coronary Heart Disease.- Regulation of Apolipoprotein A-I Gene Expression, Synthesis, and Function.- The Many and Varied Functions of HDL.- HDL Particle Composition, Proteomics, and Metabolism.- HDL Structure, Function, and Anti-inflammatory Properties.- Human ApoA-I Deficiency.- Human ApoA-I Variants.- Cellular Cholesterol Efflux 1: ABCA 1 Function and Deficiency.- Cellular Cholesterol Efflux 2: ABCG1 Function.- Cellular Cholesterol Efflux 3: ABCA1, ABCG1 and HDL Particle Interaction.- Cholesterol Esterification and Human LCAT Deficiency.- Effects of Lipoprotein Lipase and Hepatic Lipase Deficiency on HDL Metabolism.- Cholesteryl Ester Transfer Protein (CEPT) and Human CETP Deficiency.- HDL Metabolism and Scavenger Receptor B1.- The Genetics of HDL.- Effects of Nutrition and Excersize on HDL Metabolism.- Effects of Alcohol on HDL Metabolism.- Effects of Estrogens on HDL Metabolism.- Efects of Niacin on HDL Metabolism.- Effects of Statins on HDL Metabolism.- Effects of Fibrates on HDL Metabolism.- Effects of Cholesterol Ester Transfer Protein Inhibition on HDL Metabolism.- Oral and HDL Infusion Therapy to Enhance Reverse Cholesterol Transport.- Conclusions.