Lysophospholipid Receptors

The current state of the science supporting new research in lysophospholipids The study of lysophospholipids exploded with the discovery of cell surface receptors on both lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Since then, thousands of original research reports ranging from fundamental cell signaling to the physiology and pathophysiology of individual organ systems have centered on lysophospholipids. This book draws together and analyzes the current literature to provide readers with a state-of-the-science review as well as current techniques that support research in all aspects of the field of lysophospholipid signaling. Lysophospholipid Receptors is divided into three sections: Receptors and other possible effectors Enzymes Physiology and pathophysiology Within each section, the authors explain the similarities and differences between LPA and S1P signaling. Examples are provided that demonstrate the underlying mechanisms of lysophospholipid signaling across a broad range of organ systems, such as S1P signaling in cardiovascular physiology and disease and the neural effects of LPA signaling. Extensive references at the end of each chapter provide a gateway to the literature and facilitate further research into individual topics. Each chapter has been authored by one or more leading international authorities in lysophospholipid research. Based on a thorough analysis of the current research, the authors set forth what is established science and offer their expert opinion and perspective on new and emerging areas of research, setting the stage for further investigations that will solve current problems in the field.

The current state of the science supporting new research inlysophospholipidsThe study of lysophospholipids exploded with the discovery ofcell surface receptors on both lysophosphatidic acid (LPA) andsphingosine 1-phosphate (S1P). Since then, thousands of originalresearch reports--ranging from fundamental cell signaling tothe physiology and pathophysiology of individual organsystems--have centered on lysophospholipids. This book drawstogether and analyzes the current literature to provide readerswith a state-of-the-science review as well as current techniquesthat support research in all aspects of the field oflysophospholipid signaling.Lysophospholipid Receptors is divided into threesections:* Receptors and other possible effectors* Enzymes* Physiology and pathophysiologyWithin each section, the authors explain the similarities anddifferences between LPA and S1P signaling. Examples are providedthat demonstrate the underlying mechanisms of lysophospholipidsignaling across a broad range of organ systems, such as S1Psignaling in cardiovascular physiology and disease and the neuraleffects of LPA signaling. Extensive references at the end of eachchapter provide a gateway to the literature and facilitate furtherresearch into individual topics.Each chapter has been authored by one or more leadinginternational authorities in lysophospholipid research. Based on athorough analysis of the current research, the authors set forthwhat is established science and offer their expert opinion andperspective on new and emerging areas of research, setting thestage for further investigations that will solve current problemsin the field.