Equine Genomics

Equine Genomics Equine genetics has long been studied as a means of improving traits such as performance capabilities and coat color in horses. Dramatic advances in genomics and high-throughput DNA analysis technologies have significantly increased our understanding of the molecular biology of growth, development, and disease. Equine Genomics focuses on the significant advances in genome-mapping and genomic technologies and their application to the improvement of equine traits of economic significance. Equine Genomics provides broad-ranging coverage of advances in genome science as applied to horses. The opening chapters provide strong foundational information on defining the equine genome, the development of genetic linkage, physical and comparative maps, as well as whole genome sequences. The following several chapters then look at the underlying genetics of key traits, such as reproduction, coat color, performance, and a variety of key diseases impacting horses. The final chapter looks at equine mitochondrial DNA and its implication on equid evolution and genetic diversity. A timely and vitally important resource, Equine Genomics, is an essential title for animal scientists, genomic researchers, veterinary scientists, equine breeders, and industry personnel.

Equine GenomicsEquine genetics has long been studied as a means of improving traits such as performance capabilities and coat color in horses. Dramatic advances in genomics and high-throughput DNA analysis technologies have significantly increased our understanding of the molecular biology of growth, development, and disease. Equine Genomics focuses on the significant advances in genome-mapping and genomic technologies and their application to the improvement of equine traits of economic significance.Equine Genomics provides broad-ranging coverage of advances in genome science as applied to horses. The opening chapters provide strong foundational information on defining the equine genome, the development of genetic linkage, physical and comparative maps, as well as whole genome sequences. The following several chapters then look at the underlying genetics of key traits, such as reproduction, coat color, performance, and a variety of key diseases impacting horses. The final chapter looks at equine mitochondrial DNA and its implication on equid evolution and genetic diversity.A timely and vitally important resource, Equine Genomics, is an essential title for animal scientists, genomic researchers, veterinary scientists, equine breeders, and industry personnel.

Contributors ixPreface xiChapter 1 Defining the equine genome: The nuclear genome and the mitochondrial genome 1Bhanu P. ChowdharyChapter 2 Genetic linkage maps 11June Swinburne and Gabriella LindgrenChapter 3 Physical and comparative maps 49Terje Raudsepp and Bhanu P. ChowdharyChapter 4 The Y-chromosome 73Terje Raudsepp, Nandina Paria, and Bhanu P. ChowdharyChapter 5 Unexpected structural features of the equine major histocompatibility complex 93Loren C. Skow and Candice L. Brinkmeyer-LangfordChapter 6 Assembly and analysis of the equine genome sequence 103Claire M. WadeChapter 7 Genomic tools and resources: Development and applications of an equine SNP genotyping array 113Molly McCue and Jim MickelsonChapter 8 Functional genomics 125Stephen J. Coleman, Michael J. Mienaltowski, and James N. MacLeodChapter 9 Coat color genomics 143Samantha A. Brooks and Rebecca R. BelloneChapter 10 Genomics of skin disorders 155Amy E. Young, Stephen D. White, and Danika L. BannasvchChapter 11 Genomics of muscle disorders 171James R. Mickelson, Stephanie J. Valberg, Carrie J. Finno, and Molly E. McCueChapter 12 Genomics of skeletal disorders 187Ottmar DistlChapter 13 Genomics of reproduction and fertility 199Terje Raudsepp, Pranab J. Das and Bhanu P. ChowdharyChapter 14 Genetics of equine neurologic disease 217Carrie J. Finno and Monica AlemanChapter 15 Molecular genetic testing and karyotyping in the horse 241M. C. T. Penedo and Terje RaudseppChapter 16 Genomics of laminitis 255Jim K. BelknapChapter 17 Genomics of performance 265Emmeline W. Hill, Lisa M. Katz, and David E. MacHughChapter 18 Genomics of the circadian clock 285Barbara A. MurphyChapter 19 Mitochondrial genome: Clues about the evolution of extant equids and genomic diversity of horse breeds 311Cynthia C. Steiner, Kateryna D. Makova, and Oliver A. RyderIndex 323