Flexible Viruses

This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.

This book provides up-to-date information on experimental and computational characterization of the structural and functional properties of viral proteins, which are widely involved in regulatory and signaling processes. With chapters by leading research groups, it features current information on the structural and functional roles of intrinsic disorders in viral proteomes. It systematically addresses the measles, HIV, influenza, potato virus, forest virus, bovine virus, hepatitis, and rotavirus as well as viral genomics. After analyzing the unique features of each class of viral proteins, future directions for research and disease management are presented.

Preface.1. Do viral proteins possess unique features? (VladimirUversky).2. Functional role of structural disorder in capsid proteins(Lars Liljas).3. Structural disorder within the nucleoproteins andphosphoproteins of measles, Nipah and Hendra viruses (JohnnyHabchi and Sonia Longhi).4. Structural disorder within the Sendai virus nucleoprotein andphosphoprotein (Rob Ruigrok and Martin Blackledge).5. Structural disorder in Rhabdoviridae phosphoproteins (MarcJamin).6. Structural disorder in matrix proteins from HiV-relatedviruses (Vladimir Uversky and Keith Dunker).7. Structural disorder in proteins from influenza virus(Vladmir Uversky and Keith Dunker).8. Structural disorder in the HIV-1 Vif protein andoilgomerization-dependent gain of structure (AssafFriedler).9. Order from Disorder: Structure, Function and Dynamics of theHIV-1 Transactivator of Transcription (Joe D.O'Neil).10. Intrinsically disordered protein domains of the nonstructural proteins of Sesbania mosaic virus and their functionalrole (Handanahal S. Savithri).11. Intrinsic disorder in genome-linked viral proteins VPgs ofpotyviruses (Jadwiga Chroboczek, Eugénie HébrardKristiina Mäkinen, Thierry Michon and KimmoRantalainen).12. Intrinsic disorder in HPV 16 E7 protein (Gonzalo dePrat-Gay).13. The Semiliki forest virus serine protease is disordered andyet displays catalytic activity (Manuel Morillas).14. Intrinsic disorder in the core proteins ofFlaviviridae (Jean-Luc Darlix).15. Domains 2 and 3 of non-structural protein 5A (NS5A) ofhepatitis C virus is natively unfolded (Ho Sup Yoon).16. Intrinsic disorder within phage lambda N protein andinteraction with the E. coli NusA protein (KristianSchweimer).17. The N-terminal extension region of Hordeivirusmovement TGB1 protein consists of two domains with differentcontent of disordered structure (V.V. Makarov, M.E. TailanskyE.N. Dobrov, N.O. Kalinina).