Drug Delivery

An indispensable tool for those working at the front lines of new drug development Written for busy professionals at the forefront of new drug development, Drug Delivery gets readers quickly up to speed on both the principles and latest applications in the increasingly important field of drug delivery. Recent developments in such areas as combinatorial chemistry, proteomics, and genomics have revolutionized researchers' ability to rapidly identify and synthesize new pharmacological compounds. However, delivery-related properties remain a significant reason for clinical trial failures. Bringing together contributions by leading international experts, Drug Delivery covers the entire field in a systematic but concise way. It begins with an in-depth review of key fundamentals, such as physiochemical and biological barriers; drug delivery pathways; metabolism; drug formulation; pharmacokinetic and pharmacodynamic issues; and more. The remainder of the book is devoted to the systematic examination-including overviews, timely examples, and extensive references-of a host of specific subjects, including: * Receptor-mediated drug delivery * Prodrug delivery approaches * Oral protein and peptide drug delivery * Gene therapy and gene delivery * Ultrasound-mediated drug delivery * Polycationic peptides and proteins in drug delivery * Pulmonary drug delivery * Antibody-directed drug delivery * Efflux transporters in drug excretion * Intellectual property issues in drug delivery

An indispensable tool for those working at the front lines of newdrug developmentWritten for busy professionals at the forefront of new drugdevelopment, Drug Delivery gets readers quickly up to speed on boththe principles and latest applications in the increasinglyimportant field of drug delivery.
Recent developments in such areas as combinatorial chemistry,proteomics, and genomics have revolutionized researchers' abilityto rapidly identify and synthesize new pharmacological compounds.However, delivery-related properties remain a significant reasonfor clinical trial failures.
Bringing together contributions by leading international experts,Drug Delivery covers the entire field in a systematic but conciseway. It begins with an in-depth review of key fundamentals, such asphysiochemical and biological barriers; drug delivery pathways;metabolism; drug formulation; pharmacokinetic and pharmacodynamicissues; and more. The remainder of the book is devoted to thesystematic examination-including overviews, timely examples, andextensive references-of a host of specific subjects,including:
* Receptor-mediated drug delivery
* Prodrug delivery approaches
* Oral protein and peptide drug delivery
* Gene therapy and gene delivery
* Ultrasound-mediated drug delivery
* Polycationic peptides and proteins in drug delivery
* Pulmonary drug delivery
* Antibody-directed drug delivery
* Efflux transporters in drug excretion
* Intellectual property issues in drug delivery

Preface vii
List of Contributors ix
1 Factors That Impact the Developability of Drug Candidates: An Overview 1
Chao Han and Binghe Wang
2 Physiological, Biochemical, and Chemical Barriers to Oral Drug Delivery 15
Anna Maria Calcagno and Teruna J. Siahaan
3 Pathways for Drug Delivery to the Central Nervous System 29
Yan Zhang and Donald W. Miller
4 Physicochemical Properties, Formulation, and Drug Delivery 57
Dewey H. Barich, Mark T. Zell, and Eric J. Munson
5 Targeted Bioavailability: A Fresh Look at Pharmacokinetic and Pharmacodynamic Issues in Drug Delivery 73
William F. Elmquist
6 Presystemic and First-Pass Metabolism 83
W. Griffith Humphreys
7 Cell Culture Models for Drug Transport Studies 103
D. Nedra Karunaratne, Peter S. Silverstein, Veena Vasandani, Amber M. Young, Erik Rytting, Bradley Yops, and Kenneth L. Audus
8 Prodrug Approaches to Drug Delivery 125
Longqin Hu
9 Receptor-Mediated Drug Delivery 167
Christopher P. Leamon and Philip S. Low
10 Oral Protein and Peptide Drug Delivery 189
Rick Soltero
11 Metabolic Activation and Drug Targeting 201
Xiangming Guan
12 Ultrasound-Mediated Drug Delivery 245
Ka-yun Ng and Terry O. Matsunaga
13 Polycationic Peptides and Proteins in Drug Delivery: Focus on Nonclassical Transport 279
Lisa A. Kueltzo and C. Russell Middaugh
14 Gene Therapy and Gene Delivery 305
Naoki Kobayashi, Makiya Nishikawa, and Yoshinobu Takakura
15 Parenteral Formulation for Peptides, Proteins, and Monoclonal Antibodies Drugs: A Commercial Development Overview 321
John A. Bontempo
16 Pulmonary Drug Delivery: Pharmaceutical Chemistry and Aerosol Technology 341
Anthony J. Hickey
17 Antibody-Directed Drug Delivery 363
Herve´ Le Calvez, John Mountzouris, Kosi Gramatikoff, and Fang Fang
18 Efflux Transporters in Drug Excretion 381
Shuzhong Zhang and Marilyn E. Morris
19 Liposomes as Drug Delivery Vehicles 411
Guijun Wang
20 Regulatory and Intellectual Property Issues in Drug Delivery Research 435
Shihong Nicolaou
Index 443