The Molecular Biology and Pathology of Elastic Tissues

Drawing together contributions from a diverse group of international experts in the field, this collection of papers examines the biology and pathology of elastin at the molecular level. Topics include the structure, ultrastructure and function of elastin; elastin regulation; elastin's role in aging, lung development and disease and atherosclerosis; as well as related aspects of pharmacology and nutrition.

Drawing together contributions from a diverse group of international experts in the field, this collection of papers examines the biology and pathology of elastin at the molecular level. Topics include the structure, ultrastructure and function of elastin; elastin regulation; elastin's role in aging, lung development and disease and atherosclerosis; as well as related aspects of pharmacology and nutrition.

Partial table of contents:Molecular Biophysics of Elastin Structure, Function andPathology (D. Urry, et al.).Ultrastructure of Elastin (I. Pasquali-Ronchetti, etal.).GENERAL DISCUSSION I: HYDROXYLATION OF THE PENTAPEPTIDE VGVPG INOVINE ELASTIN.Structure of the Elastin Gene (J. Rosenbloom, etal.).Catalytic Properties and Structural Components of Lysyl Oxidase(H. Kagan, et al.).GENERAL DISCUSSION II: EVOLUTIONARY ASPECTS.The Structure and Function of Fibrillin (D. Reinhardt, etal.).Elastin Gene Mutations in Transgenic Mice (J. Sechler, etal.).GENERAL DISCUSSION III: Elastin in Lung Development and Disease(R. Pierce, et al.).Elastin in Systemic and Pulmonary Hypertension (F. Keeley &L. Bartoszewicz).GENERAL DICUSSION IV: DEVELOPMENTAL REGULATION OF ELASTINPRODUCTION.Elastin in Blood Vessels (L. Robert, et al.).GENERAL DISCUSSION V: THE NON-ENZYMIC GLYCATION OF ELASTIN.Interaction of Tumour Cells with Elastin and the MetastaticPhenotype (J. Tímár, et al.).A Role for Neutrophil Elastase in Solar Elastosis (B. Starcher& M. Conrad).Indexes.