Beschreibung:
The authoritative reference on recent developments in vaccinology New technologies, including recombinant protein and DNA, have sparked phenomenal progress in vaccine development and delivery systems. This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. With chapters written by leading experts in their fields, Vaccine Adjuvants and Delivery Systems: * Provides a comprehensive overview of the rapidly evolving field and developing formulation methods * Covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage * Includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more * Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions * Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants A great reference for researchers, scientists, and students in vaccinology, biotechnology, immunology, and molecular biology, this resource is also valuable for researchers and scientists in veterinary medicine who work to prevent diseases in animals.
The authoritative reference on recent developments invaccinologyNew technologies, including recombinant protein and DNA, havesparked phenomenal progress in vaccine development and deliverysystems. This unique resource brings scientists up to date onrecent advances and provides the information they need to selectcandidate adjuvants. With chapters written by leading experts intheir fields, Vaccine Adjuvants and Delivery Systems:* Provides a comprehensive overview of the rapidly evolving fieldand developing formulation methods* Covers cutting-edge technologies and gives the current status ofadjuvants in clinical trials and those still in the pre-clinicalstage* Includes detailed information on specific vaccine adjuvantsincluding MF59, TLR4 agonists, new iscoms, cytokinespolyphosphazenes, and more* Provides a historical perspective on the development of vaccineadjuvants and discusses the mechanisms of adjuvant actions* Covers some novel adjuvants and delivery systems and the safetyevaluation of adjuvantsA great reference for researchers, scientists, and students invaccinology, biotechnology, immunology, and molecular biology, thisresource is also valuable for researchers and scientists inveterinary medicine who work to prevent diseases in animals.
Contributors viiPreface ix1 Development of Vaccine Adjuvants: A Historical Perspective 1Gary Ott and Gary Van Nest2 Antigen Processing and Presentation 33Subash Sad3 Mechanisms of Adjuvant Action 53Nils Lycke4 Aluminum-Containing Adjuvants: Properties, Formulation, and Use 81Stanley L. Hem and Harm HogenEsch5 MF59: A Safe and Potent Oil-in-Water Emulsion Adjuvant 115Derek T. O'Hagan and Manmohan Singh6 TLR4 Agonists as Vaccine Adjuvants 131David A. Johnson and Jory R. Baldridge7 Immunostimulatory CpG Oligodeoxynucleotides as Vaccine Adjuvants 157Dennis M. Klinman, Debbie Currie, and Hidekazu Shirota8 Small Molecule Immunopotentiators as Vaccine Adjuvants 175Fengfeng Xu, Nicholas M. Valiante, and Jeffrey B. Ulmer9 New ISCOMs Meet Unsettled Vaccine Demands 191Bror Morein, Kefei Hu, Karin Lövgren, and Erik D'Hondt10 Surface-Charged Poly(lactide-co-glycolide) Microparticles as Novel Antigen Delivery Systems 223Manmohan Singh, James Chesko, Jina Kazzaz, Mildred Ugozolli, Padma Malyala, and Derek T. O'Hagan11 Liposomal Cytokines and Liposomes Targeted to Co-Stimulatory Molecules as Adjuvants for HIVSubunit Vaccines 249Bulent Ozpolat and Lawrence B. Lachman12 Archaeosome Vaccine Adjuvants for Cross-Priming CD8+T-Cell Immunity 263Lakshmi Krishnan and G. Dennis Sprott13 Mucosal Adjuvants and Delivery Systems 295Michael Vajdy14 Cytokines as Vaccine Adjuvants 327Nejat K. Egilmez15 Polyphosphazenes as Vaccine Adjuvants 355Alexander K. Andrianov16 Vaccine Delivery by Transdermal Electroporation 379Amit Misra17 Nonclinical Safety Assessment of Vaccines and the Evaluation of Novel Adjuvants and Delivery Systems 403Jose A. Lebron, Jayanthi J. Wolf, Catherine V. Kaplanski, and Brian J. Ledwith18 Safety Evaluation of Vaccine Adjuvants 421Erik B. LindbladIndex 445