Handbook of the Biology of Aging

Dr. Nicolas Musi is a tenured Professor of Medicine (Division of Geriatrics and Gerontology and Division of Diabetes) and Director of the Barshop Institute for Longevity and Aging Studies, the San Antonio Claude D. Pepper Older Americans Independence Center, and the San Antonio Geriatric Research, Education and Clinical Center. He is an active educator and research mentor, and supervises clinical and research fellows, residents and graduate students. In this role, he also functions as Director of a T32 Training Grant on the Biology of Aging.Dr. Peter Hornsby obtained a Ph.D. in Cell Biology at the Institute of Cancer Research of the University of London. He has held faculty positions at the University of California SanDiego, the Medical College of Georgia, and Baylor College of Medicine. Currently he is Professor in Department of Physiology and Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio.

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems.

The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others.

• Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition
• Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline
• Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline
• Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering
• New chapters on genetics, evolutionary biology, bone aging, and epigenetic control
• Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Foreword Preface

Section I: Basic Mechanisms of Aging: Models and Systems

Chapter 1 - Longevity as a Complex Genetic Trait George L. Sutphin and Ron Korstanje

Chapter 2 - The mTOR Pathway and Aging Katherine H. Schreiber, Monique N. O'Leary, and Brian K. Kennedy

Chapter 3 - Sirtuins, Healthspan, and Longevity in Mammals William Giblin and David B. Lombard

Chapter 4 - The Hypoxic Response and Aging Scott F. Leiser, Hillary A. Miller, and Matt Kaeberlein

Chapter 5 - The Role of Neurosensory Systems in the Modulation of Aging Michael J. Waterson and Scott D. Pletcher

Chapter 6 - The Naked Mole-Rat: A Resilient Rodent Model of Aging, Longevity, and Healthspan Kaitlyn N. Lewis and Rochelle Buffenstein

Chapter 7 - Contributions of Telomere Biology to Human Age-Related Disease Ting-Lin B. Yang, Shufei Song, and F. Brad Johnson

Chapter 8 - Systems Approaches to Understanding Aging Lei Hou, Dan Wang, Hao Cheng, Bo Xian, and Jing-Dong J. Han

Chapter 9 - Integrative Genomics of Aging João Pedro de Magalhães and Robi Tacutu

Chapter 10 - NIA Interventions Testing Program: A Collaborative Approach for Investigating Interventions to Promote Healthy Aging Nancy L. Nadon, Richard A. Miller, Randy Strong, and David E. Harrison

Chapter 11 - Comparative Biology of Aging: Insights from Long-Lived Rodent Species Michael Van Meter, Vera Gorbunova, and Andrei Seluanov

Section II: The Pathobiology of Human Aging

Chapter 12 - Genetics of Human Aging Miook Cho and Yousin Suh

Chapter 13 - The Aging Arterial Wall Mingyi Wang, Robert E. Monticone, and Edward G. Lakatta

Chapter 14 - Age-Related Alterations in Neural Plasticity Shannon J. Moore and Geoffrey G. Murphy

Chapter 15 - The Aging Immune System: Dysregulation, Compensatory Mechanisms, and Prospects for Intervention Ludmila Müller and Graham Pawelec

Chapter 16 - Vascular Disease in Hutchinson Gilford Progeria Syndrome and Aging: Common Phenotypes and Potential Mechanisms Ingrid A. Harten, Michelle Olive, and Thomas N. Wight

Chapter 17 - Cardiac Aging Dao-Fu Dai, Ying-Ann Chiao, Robert J. Wessells, Rolf Bodmer, Hazel H. Szeto, and Peter S. Rabinovitch

Chapter 18 - Current Status of Research on Trends in Morbidity, Healthy Life Expectancy, and the Compression of Morbidity Eileen M. Cr4immins and Morgan E. Levine

Chapter 19 - On the Compression of Morbidity: From 1980 to 2015 and Beyond James F. Fries